Pinnacle offers FAST SCAN CYCLIC VOLTAMMETRY SYSTEMS (FSCVs) to measure biogenic amines (e.g. dopamine) wirelessly in rats and tethered in mice. FSCV is a method whereby biogenic amine levels are detected by rapidly cycling a voltage across an implanted carbon fiber microelectrode and measuring the resultant current. Pinnacle’s FSCV systems can measure spontaneous sub-second neurotransmitter release events while conducting detailed behavioral studies.
The RAT WIRELESS SYSTEM allows researchers to monitor neurotransmitter release in situations where a traditional tether system may not be practical such as mazes, enclosed behavioral or metabolic chambers. The development of this technology will open new doors to research and discovery about the underlying neurochemical events associated with behavior and allow researchers to evaluate the complex relationships in ways that are currently not possible.
The TETHERED FSCV SYSTEM will allow researchers to harness the powerful genetics of the mouse model to address the underlying mechanisms of catechol neurotransmitter release and function. The tethered system for mice and the wireless system for rats allow for experimental designs currently not possible with other systems.
This screenshot shows the current change from baseline resulting from a one umol of dopamine injection into a flow cell. Pinnacle’s 30 micron carbon fiber electrode, FSCV hardware, and FSCV software (shown) were used to record the data.